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Characterising the biodiversity of collections, from taxonomy to biological activities.

CIRM is involved in research projects to assess the biodiversity of its collections and the associated enzymatic, metabolic or biological potential. These objectives require systematic sequencing of genomes and phenotypic characterisation using automated screening devices. It also participates in the exploration of the microbial biodiversity present in environments of agronomic and environmental interest.

• Genomics: Taxonomy / phylogenomics / gene discovery and enzymatic potential / metabolic profiling / dereplication / reference strain sets
• Metabolism - Enzymatic activities: Metabolism of oligosaccharides / production of vitamins, exopolysaccharides, aromatic compounds / cellulolytic activities / degradation of industrial pollutants
• Biological activity Antifungal activity / production of bacteriocins / antibiotic resistance profiles according to EUCAST/CASFL procedures / anti-inflammatory properties.

Recent publications:

• Large-scale phenotyping of 1,000 fungal strains for the degradation of non-natural, industrial compounds Commun Biol . 2021 Jul 15;4(1):871. doi: 10.1038/s42003-021-02401-w.
• Quantifying the effect of human practices on S. cerevisiae vineyard metapopulation diversity Sci Rep . 2020 Oct 1;10(1):16214. doi: 10.1038/s41598-020-73279-7.
• Microbial Diversity Associated with Gwell, a Traditional French Mesophilic Fermented Milk Inoculated with a Natural Starter Microorganisms . 2020 Jun 30;8(7):982. doi: 10.3390/microorganisms8070982